Smallpox rickettsiosis is a benign rickettsiosis infection that is manifested by specific intoxication. Rickettsial smallpox is characterized by generalized erythematous papulo-vesicular rashes on the palms, soles and mucous membranes following the primary lesion at the bite site of the mouse mite vector. By the time the temperature rises, a scab develops in this place. The systemic disease lasts about one week and is manifested by chills, fever, headache, myalgia, anorexia, photophobia and regional lymphadenopathy. The disease ends in self-healing, complications and deaths are unknown.

Etiology. Rickettsia smallpox is caused by Rickettsia akari, which belongs to the same group as rickettsia, which causes spotted fever, and is antigenically related to R. rickettsii.

Epidemiology. In the USA, the natural host of R. akari is Mus musculus, a common house mouse. The disease is transmitted by the mouse mite, Allodermanyssus sanguineus. The risk of disease is greater in areas populated by mice. For the first time, the disease was diagnosed in residents of apartment buildings in New York, and then found in large urban areas, according to the number of mice. All age groups are affected. There are no seasonal fluctuations in the incidence. The disease is not transmitted from person to person. Currently, it is extremely rare in the USA.

The incubation period lasts from 9 to 14 days.

Diagnostic tests. R. akari can be isolated from the blood in the acute stage of the disease, but isolation attempts are possible only in specialized laboratories. The Weyl—Felix reaction to all Proteus-agglutinins is negative. Indirect immunofluorescence or CSC reveals a fourfold increase in titers of species—specific rickettsiosis antibodies in blood serum in the acute stage and during recovery, but these antibodies produce intense cross-reactions with antibodies against R. rickettsii, the causative agent of Rocky Mountain spotted fever.

Treatment. Tetracycline (which should not be given to children under 9 years of age) or chloramphenicol shortens the duration of the disease.

Isolation of a hospitalized patient. Precautions are not recommended.

Control measures. Disinfection using residual insecticides and rodent control measures limit or destroy the vector. There are no specific measures for people who have been in contact. Le bonus de bienvenue est l’argument commercial principal. Pourtant, tous les bonus de bienvenue ne se valent pas. Notre analyse montre que le taux de transformation dépend du sites de paris sportifs meilleur bookmaker pour le live et des exigences de mise. Un bonus de 500% sur 5 dépôts impose souvent 35x de wagering. Préférez un bonus de 100% sur le premier dépôt avec 5x de mise. Cela permet un retrait plus rapide des gains. Lisez aussi les restrictions sur les paris combinés. Certains bookmakers n’acceptent que des paris simples. Notre comparatif met en avant les offres les plus rentables et les plus transparentes.